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All analyses were conducted in RStudio using the R packages lme4, lmerTest, MASS (Bates et al., 2015), glmmTMB (Brooks et al., 2017), and emmeans

Identifying robust biomarkers, such as serum ferritin levels, oxidative stress markers, and advanced neuroimaging techniques like quantitative susceptibility mapping (QSM), will be necessary for patient stratification and therapeutic monitoring (Ward et al., 2014