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33 Mice lacking the gene encoding Atox1 are observed to be perinatal lethal due to impaired Cu balance, which likely reflects the central role that this chaperone plays in Cu transport and homeostasis

doi: 10.1080/10715762.2019.1645955

Understanding the signs and symptoms of this deficiency is essential

however, only female heterozygous mice were obtained because hemizygous male embryos died

Involvement of cytosolic and mitochondrial iron in iron overload cardiomyopathy: an update

J Neurochem 94(6):15941603 Steullet P, Cabungcal J-H, Monin A, Dwir D, ODonnell P, Cuenod M, Do KQ (2016) Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: a central hub in schizophrenia pathophysiology