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PI3K/mTOR inhibitors induce synergistic anti-proliferative and pro-apoptotic effects by inhibiting the kinase activity of the CDK/cyclin complex and, consequently, preventing phosphorylation of the Rb protein (Cretella et al

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Gonzales MM, Garbarino VR, Kautz TF, Palavicini JP, Lopez-Cruzan M, Dehkordi SK, Mathews JJ, Zare H, Xu P, Zhang B, Franklin C, Habes M, Craft S, Petersen RC, Tchkonia T, Kirkland JL, Salardini A, Seshadri S, Musi N, Orr ME

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B12 is essential to nerve health, so it makes sense that a deficiency would impact the optic nerve health as well