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It has been approved by the FDA for several Phase I clinical trials in advanced cancers [107]

Despite these diverse origins, such as metabolic dysfunction, immune attack, toxic exposure or vascular injury, the pathophysiological mechanisms involved tend to converge on a common pathway characterized by inflammation, fibrosis, nephron loss and eventual functional failure [15,16,17,18]

Exp Neurol 198:361369

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The APRN follow-up at this stage assesses response and determines whether protocol continuation, dose adjustment, or stack modification is appropriate