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In mammals, the ribosome stalling induced by genotoxic stress such as ultraviolet light-B or 4-nitroquinoline 1-oxide stress recruits ASCC3, however, ASCC3 failed to resolve them, resulting in a prolonged cell-cycle arrest through the ZAK-p38MAPK signaling axis (Stoneley et al, 2022)

Accumulating evidence has indicated that Schwann-like cells induced from different types of stem cells, including embryonic stem cells (ESC), induced pluripotent stem cells (iPSC), and various multipotent postnatal stem cells, represent important alternative sources of Schwann cells, among which mesenchymal stem/stromal cells (MSCs) readily isolated from a variety of tissues, such as bone marrow, skin, adipose, umbilical cord, and dental tissues, are the major source of Schwann-like cells for cell-based therapy of PNIs [33]

doi: 10.1093/ajcn/85.3.702

White, Ph.D