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The Ozempic ladder reaches 2.0 mg weekly, but doubling from 1.0 to 2.0 mg added only about 0.23 percentage points of HbA1c reduction and 0.9 kg of weight loss. Beyond 1.0 mg, most of the added effect is on weight rather than glucose

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Additional controlled human research in individuals with sleep disturbances suggests that DSIP can normalize disrupted sleep patterns, extending periods of sleep with fewer awakenings and improved overall quality

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DOI: 10.1016/j.bbrc.2019.03.088