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They exert their therapeutic effects by modulating molecular signaling networks central to tissue regeneration

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In 1931, during the Great Depression, Texas and other states created a movement that sought to "reform the administrative machinery, and to reduce the high cost of state government." [4] The Texas Legislature enrolled Griffenhagen and Associates, "specialists in public administration and finance who had worked on similar projects throughout the United States and Canada, to make a survey and act as consultants." [4] The firm concluded that Texas' exceptional geographic size caused the Rangers and the License and Weight Division to struggle in providing adequate enforcement across the entire state

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The typical outcome measure used by researchers is the Sciatic Function Index that assesses hind limb motor function based on toe to toe and toe to heel distance