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CRC Press, Florida, USA

Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2

Senomorphics A class of therapeutics that reduce the toxicity of senescent cells by dampening their secretome (e.g., SASP)

More recently, an analog of BEZ (mito-BEZ) with increased mitochondrial localization significantly reduced both PMN-MDSCs and M-MDSCs, while increasing tumor infiltration of CD8 + T cells, highlighting BEZ as a potential combinatorial therapy with ICB to target MDSC-mediated immunosuppression on T cells (165)