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The results reveal that LPS promoted HDF migration, as indicated by the scratch wound healing assay, whereas the application of the p38/MAPK inhibitor SB203580 largely abolished this effect (Figures 5A,B)

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"Centenarians display plasma MOTS-c concentrations significantly higher than age-matched peers, a pattern that closely resembles levels found in individuals decades younger suggesting preserved mitochondrial signaling as a hallmark of exceptional longevity." The connection to cellular senescence deserves further attention here