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95,96 Although alcohol dehydrogenase can metabolize alcohol relatively safely to acetaldehyde that is converted to acetate by mitochondria, chronically high alcohol consumption results in a relative increase in alcohol metabolism by the cytochrome p450 enzyme CYP2E1, a pathway that generates ROS

Swisher SG , Holmes EC, Hunt KK, Gornbein JA, Zinner MJ, McFadden DW

Simonds, W

Violent suicidal behaviour in bipolar disorder is associated with nitric oxide synthase 3 gene polymorphism

Try cutting back little by little (or all at once, if you can) until you reach a moderate intake