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A washout period of at least 1 week separated the 2 arms

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Taking 1 mL working solution as an example, add 100 L DMSO stock solution ( 67.5 mg/mL ) to 900 L 20% SBE--CD in Saline, and mix evenly

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However, its important to emphasize that this number is considered a minimum daily allotment, and there is no established upper limit