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6.1 Mechanisms underlying treatment of UC The treatment of UC involves the modulation of various immunoinflammatory pathways, including the activation and suppression of key mechanisms such as PPAR, Nrf2, NF-kB, and macrophages, along with the regulation of the Th17/Treg balance [61]

Important social, occupational, or recreational activities are given up or reduced because of opioid use

( Figure 2 ) In addition, TLR antagonists also showed therapeutic potential in pre-clinical models with tumors in the digestive system, but the potency of this group of agents in human remains to be fully elucidated

[PubMed: 12376586] 57

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