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When levels are high or symptoms like confusion, breathing problems, or loss of consciousness appear

iScience 27 , 110095 (2024)

Yu C, Li CH, Chen S et al (2018) Decreased BDNF release in cortical neurons of a knock-in mouse model of Huntingtons disease

the FDA advisory committee then voted against permitting their compounding, leaving them restricted (source)

Food and Drug Administration: Concerns with Unapproved GLP-1 Drugs:

Side effects from B12 supplementation are uncommon but may include: Mild gastrointestinal symptoms such as nausea or diarrhoea, typically with very high oral doses Headache or dizziness in some individuals Skin reactions (rash, itching) at injection sites when using intramuscular preparations Rare but serious allergic reactions, including anaphylaxis with injectable forms Hypokalaemia (low potassium) may occur during rapid correction of severe megaloblastic anaemia If you experience symptoms of a severe allergic reaction (difficulty breathing, severe rash, swelling of face or throat) after taking B12, seek immediate medical attention