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Molecular modeling suggested that AEDG may bind to histone H1 regions that interact with DNA, providing a proposed epigenetic mechanism for changes in neurogenesis-related gene expression and protein synthesis

Menopause 15 (2), 296303

Biochem Pharmacol 2009

Future research should focus on developing more accurate PRS models and verifying their applicability in different populations

Thus, high total IGF-I levels in CKD is inadequate in suppressing the increased GH levels because of the lower IGF-I bioactivity resulting in the lack of IGF-I feedback on pituitary GH secretion (75, 77) ( Table 1