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Although their largest involvement is in nutrient and metabolic regulation, around 10% of them might cross the BBB, as shown in animal studies with mechanistic details (Monteiro-Cardoso et al., 2021)

GhGSTF12 , a glutathione S -transferase gene, is essential for anthocyanin accumulation in cotton ( Gossypium hirsutum L.)

, the full threatening circuit in paracetamol's acute hepatic toxicity)

Ann Transl Med 2019;7:S64

Through metagenomic sequencing and in vitro coculture experiments of peripheral blood mononuclear cells (PBMCs), it was verified that butyrate can selectively expand peripheral blood Tregs in RA patients, inhibit the activation of conventional T cells (Tconvs), downregulate the production of anti-citrullinated peptide antibodies (ACPA), and reduce cartilage and bone tissue damage

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