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Based on his investigations into dyes and experiments with plant poisons as well his collaboration with von Behring to develop antiserum to treat diphtheria and tetanus, Ehrlich proposed that certain foreign entities, like toxins, get recognised by specific side chains on the cell which trigger the release of additional side chains into the bloodstream where they manage to bind and neutralise the toxin

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Firstly, 3696 parallel linear models were constructed, re-setting the reference factor to compare all possible permutations of diagnostic class, with peptide quantification as outcome variables and categorical demographic information as explanatory variables: Secondly, 3696 parallel linear models were constructed with peptide quantification as outcome variables, and continuous demographic information as explanatory variables: This similar second model was constructed to allow consideration of nuanced interparticipant differences that may be lost by stratifying individuals into discrete classes

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