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Tissue-level deficiency of cobalamin is associated with an increase in the urinary and serum concentrations of an organic acid called methylmalonic acid, which is an alternative product of a cobalamin dependent pathway within the mitochondria

There are notable resemblances between it and a bacterial protein that is linked to the two-component signal transduction system

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The PTEN-induced kinase 1 (PINK1)/Parkin pathway serves a pivotal role in the context of mitochondrial dysfunction and its association with PD

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