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BACE1: beta-site amyloid precursor protein cleaving enzyme 1

J Trauma 52:11411146 Morrison CA, Carrick MM, Norman MA, Scott BG, Welsh FJ, Tsai P, Liscum KR, Wall MJ Jr, Mattox KL (2011) Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial

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However, under oxidative stress, oxidative modification of cysteine residues in Keap1 causes conformational changes that weaken its binding to Nrf2, allowing Nrf2 to dissociate from Keap-1 and rapidly translocate to the nucleus

Santoro N, Caprio S, Giannini C, Kim G, Kursawe R, Pierpont B, Shaw MM, Feldstein AE

We always do spot testing of the area before proceeding with the actual treatment