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As described above, ghrelin and ghrelin mimetic compounds have been shown to have limited serum half lives, and are therefore not suitable for use in treating GI motility disorders

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when used alone it is typically for patients who need the ghrelin-pathway effect without a GHRH analog for a specific clinical reason

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Genetic alterations of the TGF- signaling pathway in colorectal cancer cell lines: a novel mutation in Smad3 associated with the inactivation of TGF--induced transcriptional activation