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A significant percentage of corticotroph adenomas harbor somatic mutations in USP8, and a germline mutation case have also been described and can develop Cushings disease (147,150,151)

doi: 10.1038/s41568-021-00375-9 6 SzkudliskiMLewiskiASewerynekEWajsE

This indicated enhanced ferroptosis in fibroblast-like synoviocytes (FLSs) by downregulating PI3K-AKT-ERK1/2 signaling pathway and the activation of the P53 pathway which collectively contributed to reduced cell proliferation, migration, and invasion of FLSs

However, it should be noted that docking results are only approximations and need to be validated experimentally