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As one of the lung-abundant extracellular antioxidant proteins 33 , GPX3 has the potential to fulfil an important protective function in the lung, but regulation and localization of GPX3 in ILD has received little attention

Moreover, CRSR was found to affect various ECM-associated genes, which may be responsible for its ability to decrease uterine mass (Yu et al., 2019)

The increased levels of inflammatory cytokine and chemokine genes observed in the intestinal tissues of PD patients suggest a strong connection between PD and intestinal inflammation (85, 90)

These data highlight a persistent biochemical vulnerability in individuals with reduced MTHFR activity

This mechanism also applies in the context of SCI, where enhancing Sestrin2 expression or its downstream AMPK activity effectively activates autophagy, alleviates ERS-induced neuronal damage, and promotes neuronal survival and functional recovery (Li et al., 2021