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R152 and active site residues C46, K48, Q81, and W136 are highlighted and shown as sticks

Cognitive functions in learning and memory are also compromised due to irons critical role in hippocampal development and myelin sheath formation

Alterations in the expression levels of proteins related to fission/fusion processes (such as Opa1, Drp1, MFN1/2, Fis1) 298 and post-translational modifications of Drp1 299,300 may bias mitochondria towards excessive fission, increasing mitochondrial fragmentation, leading to damage in mitochondrial energy biology and accumulation of mitochondrial DNA damage