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doi: 10.1016/S1570-9639(03)00167-5

10.1371/journal.pone.0161174 299 WangX.YangY.HuyckeM

Because human research is limited, many safety questions remain unanswered

The REDEFINE 1 trial found that treatment with CagriSema resulted in greater weight loss of 22.7% at 68 weeks versus 2.3% in the placebo group if all patients adhered to treatment.1* When evaluating the treatment effect regardless of adherence, those treated with CagriSema achieved statistically significant weight loss of 20.4% at 68 weeks versus 3.0% for the placebo group.1** In addition, a supportive secondary analysis showed that half (50.7%) of trial participants with obesity treated with CagriSema reached the threshold for non-obesity (BMI 5% (83.6% vs