glutathione peroxidase 1 located where 4: a new player in neurodegeneration? mechanism of action of glutathione

T.Stearne-CullenL

The mechanism by which this detoxification occurs is through the addition of GSH to the harmful compounds via a reaction at an electrophilic residue and the sulfhydryl residue of GSH [90]

Design Double blinded, randomised, placebo controlled fashion using high cocoa polyphenol rich chocolate in comparison to simulated iso-calorific chocolate dyed brown as placebo

Collectively, these findings suggest that the antioxidant NAC treatment successfully rescued the exacerbated ROS generation, SGNs loss, and apoptosis caused by GPX1-deficiency after peroxynitrite damage

Toxicol Appl Pharmacol 2005

CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon RB function in malignant peripheral nerve sheath tumors