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Glutathione peroxidase (GPx) is an enzyme with peroxidase activity whose main biological role is to protect the cell from oxidative damage by reducing lipid hydroperoxides to their corresponding alcohols and reducing free hydrogen peroxide to water [21]

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Modulators of mitophagy, including PINK1/Parkin activators, may enhance the clearance of damaged mitochondria and promote antifungal immunity, although their therapeutic potential requires further validation (Qin et al., 2023)

These ROS, often called free radicals, are highly unstable molecules that recklessly react with other molecules, which can damage your DNA, cells, and RNA, leading to inflammation and chronic health conditions, including headaches and migraine attacks

A recent study demonstrated that hyperoxia exposure markedly increased mtROS levels in neonatal mouse lung tissue, activated the NLRP3 inflammasome as well as promoted GSDMD cleavage dependent on caspase-1 and interleukin-1 release, ultimately resulting in macrophage pyroptosis and impaired alveolar development (Tu et al., 2025)

An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma