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In response to oxidative stress, the antioxidative system, capable of scavenging ROS, undergoes upregulation as a defense mechanism

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[21] Their three oldest children, Sandra (later Sandra Hanks Benoiton, a writer), [22] Larry (who became an entomology professor at the University of Illinois Urbana-Champaign), [23] [24] and Tom, went with their father, while the youngest, Jim (who also became an actor and filmmaker), remained with their mother in Red Bluff, California