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This is particularly consequential in post-mitotic organs such as the heart and brain, which possess limited regenerative capacity and are exceptionally vulnerable to proteotoxic stress

Cayres LC, de Salis F, Rodrigues LVV, Lengert GSP, van Biondi A, Sargentini APC, Brisotti LDB, Gomes JL, E., de Oliveira GLV

Nelson, Relation of Arginine-Lysine Antagonism to Herpes simplex Growth in Tissue Culture, Chemotherapy, vol

Moreover, DAXX protein also becomes free, which then translocates into the cytoplasm and provides the required second activation signal to the phosphorylated ASK1 protein

Also note, that a low albumin (as seen with synthetic failure or various other conditions, such as protein-losing enteropathy) resulting in decreased transport of unconjugated bilirubin to the liver is not a cause of high unconjugated bilirubin in animals

Lebel C, Beaulieu C