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NADPH also serves as a coenzyme for NADPH oxidase 2 (NOX2), which is responsible for the production of ROS and respiratory burst in leukocytes that enables the fight against microorganisms [46]

However, and perhaps the most determinant factor for the in vivo action of polyphenols, is the bioaccessibility dilemma, since transformations in food processing, particle size, type of polyphenol, digestive interactions and food matrix interactions limit the effectiveness of polyphenol assimilation [132]