glutathione s transferase estimation Overexpression of S-Transferases in Human Diseases: Drug Targets and Therapeutic Implications Glutathione-S-Transferase (GST) Activity Assay Kit

12, 2013, pp

2021 Jun 16;10(6):967

This binding transcriptionally upregulates the expression of a series of key genes, including GCLC, GCLM (the light chain of GCLC), and xCT (system xc, responsible for cysteine uptake), thereby increasing GSH synthesis and cysteine uptake, thereby strengthening the cell's antioxidant defenses

Yousef Fazel, Sundeep Kutumbaka, Arjun Srinivasan , and Iosif Vaisman

9 Proof-of-concept treatments were tested on patient fibroblasts and Pfa1 cells, which were knocked out of endogenous GPX4 and transfected to overexpress human mScarlet-tagged GPX4 WT (red) or GPX4 R152H (blue)

doi: 10.1016/j.bbrc.2020.04.127 28 Vanden BergheTVanlangenakkerNParthoensEDeckersWDevosMFestjensNet al