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This response helps coordinating a series of physiological responses that range from an increase in heart rate to the suspension of digestion and of immune responses

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Elevated plasma iron levels, in turn, lead to an increase in iron transport into parenchymal cells, particularly hepatocytes, pancreatic cells, and cardiomyocytes, leading to organ iron overload

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Targeting BRD4 mitigates hepatocellular lipotoxicity by suppressing the NLRP3 inflammasome activation and GSDMD-mediated hepatocyte pyroptosis