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The novel PVP-modified copper/hafnium-doped phosphate nanostimulator (CHP) enables cuproptosis-synergized radiosensitization under low-dose X-ray radiation and activates immunogenic cell death (ICD) to enhance anti-tumor immunity by depleting GSH, alleviating hypoxia, and reprogramming the tumor microenvironment (Jiang X

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, temperature (25 2 C), relative humidity (60 5%) and photoperiod (16 h:8 h lightdark) for several generations