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Besides, protein undergoes carbonylation, another form of protein oxidative modification in which ROS groups bind to specific amino acids, affecting protein stability and activity ( Furthermore, ROS/RNS can directly attack DNA, causing oxidative DNA damage in IBD ( 2.3 Mitochondrial dysfunction Mitochondria, with their functions in energy production, calcium homeostasis, and membrane excitability, are thought to substantially impact the pathology of IBD, as their dysfunction may initiate and advance the disease

Br J Cancer 105:16971707

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Genome-wide significant single nucleotide polymorphisms (SNPs) were identified at a threshold of p 0.1) with genome-wide significant POAG variants from previous GWAS 21