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Environmentally induced epigenetic toxicity: Potential public health concerns

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Since cognitive behavioral therapy for insomnia (CBTi) can enhance sleep quality and support endogenous antioxidant defenses, combining natural sleep interventions with pharmacological NRF2 activators such as dimethyl fumarate and sulforaphane may reinforce these pathways, stabilizing sleep patterns, reducing pain hypersensitivity, and improving fatigue

classically stimulated pro-inflammatory M1 macrophages exhibiting anticancer characteristics and (2)

doi: 10.1016/j.cld.2007.06.006

Physiol Rev 91 : 461553 This paper masterfully synthesizes how microglial cells are the best sensors of brain pathology due to their dual functions on immune and neural systems