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In addition to ECs, pericytes and astrocytes are also activated in response to peripheral inflammation, significantly impacting BBB permeability

When the FDA determines a patent-protected drug is in shortage, pharmacies are permitted to compound copies of the drug

It promotes neuronal survival, guides axon growth, and stimulates synapse formation

Such interactions have been associated with protective effects in nervous system injury models and may contribute to functional stabilization following neurological stress (3)

The Biden administration placed restrictions on these and a handful of other peptides in 2023 moving them into a category that essentially prohibits compounding pharmacies from making the drugs