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Neurology 62:17581765 Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascon S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease

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1.4.3 Limitations of benign and VUS classifications Ultimately, WES is not a genetic oracle, and in contrast to Mendelian diseases which often result from single-gene coding variants (Botstein and Risch, 2003), several complex traits could be driven by noncoding variants that presumably affect gene regulation