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In particular, increased endocannabinoid levels, down-regulation of CB1 receptors and up-regulation of CB2 receptors have been observed in intestinal specimens of CRC patients [184,185]

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This caused a long-lasting controversy whether APAP-induced cell death is caused by protein adduct formation or by oxidant stress-derived LPO

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This was predominant in the male Gclc L-KO mice and was not rescued with Nrf2 deletion (Fig