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An increase in AFB1-8, 9-epoxide cause a significant increases in hepatic LPO level [52]

Both compounds have demonstrated efficacy at inhibiting IR-induced ferroptosis in multiple organ systems by direct radical scavenging and downstream effects on the expression of other ferroptosis-related genes in irradiated tissues

doi: 10.1016/S0021-9258(17)35926-4 58 ConradMSatoH

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However, their application potential has been limited due to undesirable drug leaking during blood circulation and inefficient therapeutic efficacy in tumors, resulting in undesirable therapeutic outcomes

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