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Diabetes Care 42 , 12841289 (2019)

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Notably, several genes involved in glycolysis/gluconeogenesis (GNG) pathways, such as alcohol dehydrogenase 7 ( Adh7 ) and glucokinase ( Gck ), and genes related to antioxidant defense, including gamma-glutamyltransferase 6 ( Ggt6 ), glutathione S-transferase pi 3 ( Gstp3 ), and microsomal glutathione S-transferase 2 ( Mgst2 ), were downregulated in response to SIRT1 deletion (Fig

Animal studies have shown that when beta-3 adrenergic receptors were genetically removed, chronic AOD-9604 treatment produced no changes in weight or lipolysis, confirming the importance of this pathway