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Other mitochondrial citrate cycle enzymes, such as alpha-ketoglutarate dehydrogenase and isocitrate dehydrogenase can also be activated by Ca 2+ [21, 22]

Its also interesting that lower levels of this chemical have been found in women with a history of childhood trauma and childhood trauma is a well known risk factor for the development of depression

In patients with treatment-resistant depression, naltrexone 50 mg blocked the antidepressant but not the dissociative effects of KET, suggesting that the opioid system may also be required for KET antidepressant activities (Williams et al., 2018)