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It is intended for short-term use and may only be prescribed after a medical evaluation by a licensed provider who determines it is clinically appropriate. Phendimetrazine is FDA-approved as a short-term adjunct to a calorie-restricted diet and increased physical activity in individuals with obesity

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Studies with congenitally leptin-deficient, severely obese subjects revealed that administration of physiological doses of leptin decreased food intake and body weight (7)

For this reason, researchers prepare acetic acid water fresh or work from single-use aliquots rather than multi-use vials