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Growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood: The Environmental Determinants of Diabetes in the Young study

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43 Although p105 deficiency has no T-cell intrinsic effect on Th17 cell differentiation, the aberrant activation of NF-B renders innate immune cells hyperresponsive to TLR stimulation for production of IL-6, a major cytokine-promoting Th17 differentiation

Zhang Y, Cheng Z, Wang C, Ma H, Meng W, et al