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As stated in the CY 2025 PFS proposed rule (89 FR 61966), under CMS' proposed policy at 428.202(c)(3) and (4) to identify a payment amount benchmark period in certain instances of missing AMP and each alternative considered, CMS would consider any restatements to the AMP data used to calculate the benchmark period manufacturer price during reconciliation, as specified at 428.401(d) and described later in this final rule

Although severe and life-threatening anaemia due to PA is rare today, PA remains a specific condition that requires recognition and appropriate management

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Do not start, stop, or change a prescription medicine based on this article or an isolated laboratory result

a month.* * No healthcare provider can guarantee results for any patient

The SURMOUNT trials in patients without diabetes showed even greater weight loss, with the 15 mg dose producing an average loss of 20.9 percent of body weight at 72 weeks compared to 14.9 percent for semaglutide in similar populations