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Double-label immunofluorescence staining showed co-localization of IL-6 with F4/80 confirming that infiltrating macrophages during CP are an important source of IL-6 production and that macrophages play a role in the progression of pancreatic fibrosis ( To investigate whether the increased macrophages in the CP pancreas are mainly M1 or M2, CD11b monocytes/macrophages were selected for gene expression analysis in a mouse CP model induced by cerulein and further validated by flow cytometry that M2 macrophages, which are mainly anti-inflammatory and promote tissue repair, were predominant in CP ( In an in vitro assay, Xue et al

Cholesterol trafficking and endolysosome dysfunction The intricate relationship between cholesterol metabolism, endolysosome dysfunction and AD highlights the importance of cellular pathways that regulate intracellular trafficking, lipid metabolism, and APP processing in AD pathogenesis

doi: 10.1186/s12866-014-0324-1 33 ChowdhuryCJagannadhamMV

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