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doi: 10.3389/fphar.2020.01250 62 ZhuYHuangSChenSChenJWangZWangYet al

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In particular, pyridoxal-5-phosphate, the active form of VB6, acts as a coenzyme for aromatic L-amino acid decarboxylase, facilitating the decarboxylation of 5-hydroxytryptophan to serotonin [44]

Finally, hydrogels with good biocompatibility, low immunogenicity, and modifiable physical and chemical properties can be ideal carriers to improve efficacy and reduce the toxicity of natural products (Yegappan et al., 2018