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For naturally derived materials like sodium alginate, endotoxin levels are heavily influenced by upstream factors: Raw material sourcing Processing conditions Purification methods Once introduced, endotoxins are difficult to remove completely

28 By activating p53, the liver initiates processes that promote cell cycle arrest, DNA repair, and apoptosis in damaged cells, 29 helping to limit the extent of liver injury and facilitating the removal of cells that have sustained significant damage

By providing a forward-looking perspective, this work contributes to the rational design of functional foods, targeted therapies, and microbiome-based interventions, thereby informing future advancements in human nutrition and medicine