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M., & Lee, S

Peterson, 2020

This is supported by the fact that reaction velocity of GLXI, the rate-limiting enzyme of the pathway, is directly proportional to the concentration of GSH according to experimental data and mathematical modeling of its kinetics (Lages et al

Nature 468 (7325), 839843

The National Natural Science Foundation of China (No

In addition, Set7/9 upregulates the activity of E2F1 that in turn suppresses FOXO3 activity and mediates Sirt1 methylation on lysine residues 233, 235, 236 and 238 resulting in Sirt1 inhibition of its deacetylation activity