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118-123 Specifically, Fitzgerald et al

The suppression of ovarian FOXO1 expression effectively reversed DOX-induced follicular demise, resulting in a rise in the reserve of primordial follicles

Regarding the expression of DNMT1 and DNMT3a, our results showed that the expression of DNMT1 and DNMT3a in the ovary was significantly increased in the PCOS group, while quercetin treatment notably decreased their expression

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Sci Rep 11 , 7042 (2021)

186 Interestingly, insulin-induced ROS might induce necrosis by initiating PI3K/AKT, a prosurvival pathway, 187 suggesting context-specific ROS modulation of necroptosis (Fig