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Structurally, magnetic resonance imaging (MRI) studies reveal phenotype-dependent cortical changes: milder forms (SMA 3 and 4) show increased grey matter density in motor cortical areas in comparison to healthy controls, possibly reflecting compensatory or maladaptive plasticity [15], with greater grey matter volume correlating with longer disease duration and slower progression

doi: 10.1038/sj.ijo.0802262

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5 Conclusion and prospect Although peripheral neuropathy is a common side effect, BTZ remains a first-line treatment for MM

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