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GFAT is an important rate-limiting enzyme for Gln entry into the hexosamine pathway, and by inhibiting fructose-6-phosphate cells, it can eliminate the effector component of the extracellular matrix of the renal mesangial (37, 64)

doi: 10.1038/nrm3565 79

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Dose-response relationships appear to be tissue-specific, with adipose tissue showing high sensitivity while other tissues may require higher concentrations for detectable effects

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Testing for subcutaneous depth