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Blocking GSDME-mediated pyroptosis in renal tubular epithelial cells alleviates disease activity in lupus mice

Biometals 36 (6), 13911404

In Shank3 11/ mice, using the mGlu5 receptor PAM - CDPPB effectively alleviated behavioral deficits, including impaired sociability and repetitive behaviors, without affecting locomotor activity [54]

Simple (1:1) randomization was performed using a randomization website by the blinded clinical research coordinator

Diabetes and cognitive impairment: A role for glucotoxicity and dopaminergic dysfunction

Representative strategies targeting this axis, from glycolytic enzyme inhibitors to lactylation modulators, have advanced from preclinical validation to early-phase clinical trials, with select agents demonstrated preliminary safety and target engagement